The hepatitis B virus X protein promotes tumor cell invasion by inducing membrane-type matrix metalloproteinase-1 and cyclooxygenase-2 expression
Enrique Lara-Pezzi, … , Alicia G. Arroyo, Manuel López-Cabrera
Enrique Lara-Pezzi, … , Alicia G. Arroyo, Manuel López-Cabrera
Published December 15, 2002
Citation Information: J Clin Invest. 2002;110(12):1831-1838. https://doi.org/10.1172/JCI15887.
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Categories: Article Infectious disease

The hepatitis B virus X protein promotes tumor cell invasion by inducing membrane-type matrix metalloproteinase-1 and cyclooxygenase-2 expression

Abstract

Research Article

Authors

Enrique Lara-Pezzi, Maria Victoria Gómez-Gaviro, Beatriz G. Gálvez, Emilia Mira, Miguel A. Iñiguez, Manuel Fresno, Carlos Martínez-A., Alicia G. Arroyo, Manuel López-Cabrera

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Figure 1

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HBx induces tumor cell invasion in vivo and in vitro. (a and b) In vivo ...
HBx induces tumor cell invasion in vivo and in vitro. (a and b) In vivo invasion. CMO and CMX (a) or HepG2 and 2.2.15 (b) were analyzed for their ability to invade the CAM of a chick embryo. The results are expressed as percentage of human DNA (left) or as number of intravasated cells (right). Experiments were carried out at least in quadruplicate. (c and d) In vitro invasion. The invasive capacity of CMO and CMX (c) or HepG2 and 2.2.15 (d) cells was tested using Matrigel-coated Transwells. Cells in the underside of the filter were stained, and eight independent fields were counted. The results are expressed as the mean value ± SE of three independent points.