An open-label study to evaluate sildenafil for the treatment of lymphatic malformations
C Danial, AL Tichy, U Tariq, GL Swetman… - Journal of the American …, 2014 - Elsevier
Background Lymphatic malformations can be challenging to treat. Mainstay interventions
including surgery and sclerotherapy are invasive and can result in local recurrence and
complications. Objective We sought to assess the effect of 20 weeks of oral sildenafil on
reducing lymphatic malformation volume and symptoms in children. Methods Seven children
(4 boys, 3 girls; ages 13-85 months) with lymphatic malformations were given oral sildenafil
for 20 weeks in this open-label study. The volume of the lymphatic malformation was …
including surgery and sclerotherapy are invasive and can result in local recurrence and
complications. Objective We sought to assess the effect of 20 weeks of oral sildenafil on
reducing lymphatic malformation volume and symptoms in children. Methods Seven children
(4 boys, 3 girls; ages 13-85 months) with lymphatic malformations were given oral sildenafil
for 20 weeks in this open-label study. The volume of the lymphatic malformation was …