The negative affect of protracted opioid abstinence: progress and perspectives from rodent models
L Welsch, J Bailly, E Darcq, BL Kieffer - Biological psychiatry, 2020 - Elsevier
Opioid use disorder (OUD) is characterized by the development of a negative emotional
state that develops after a history of long-term exposure to opioids. OUD represents a true
challenge for treatment and relapse prevention. Human research has amply documented
emotional disruption in individuals with an opioid substance use disorder, at both behavioral
and brain activity levels; however, brain mechanisms underlying this particular facet of OUD
are only partially understood. Animal research has been instrumental in elucidating genes …
state that develops after a history of long-term exposure to opioids. OUD represents a true
challenge for treatment and relapse prevention. Human research has amply documented
emotional disruption in individuals with an opioid substance use disorder, at both behavioral
and brain activity levels; however, brain mechanisms underlying this particular facet of OUD
are only partially understood. Animal research has been instrumental in elucidating genes …