[HTML][HTML] Mitofusin-2 in the nucleus accumbens regulates anxiety and depression-like behaviors through mitochondrial and neuronal actions
E Gebara, O Zanoletti, S Ghosal, J Grosse… - Biological …, 2021 - Elsevier
Background Emerging evidence points to a central role of mitochondria in psychiatric
disorders. However, little is known about the molecular players that regulate mitochondria in
neural circuits regulating anxiety and depression and about how they impact neuronal
structure and function. Here, we investigated the role of molecules involved in mitochondrial
dynamics in medium spiny neurons (MSNs) from the nucleus accumbens (NAc), a hub of the
brain's motivation system. Methods We assessed how individual differences in anxiety-like …
disorders. However, little is known about the molecular players that regulate mitochondria in
neural circuits regulating anxiety and depression and about how they impact neuronal
structure and function. Here, we investigated the role of molecules involved in mitochondrial
dynamics in medium spiny neurons (MSNs) from the nucleus accumbens (NAc), a hub of the
brain's motivation system. Methods We assessed how individual differences in anxiety-like …