Peptide-binding heat shock proteins in the endoplasmic reticulum: role in immune response to cancer and in antigen presentation
PK Srivastava - Advances in cancer research, 1993 - Elsevier
Publisher Summary The demonstration of immunogenicity of cancer cells leads to a search
for the cancer-derived molecules, which elicit resistance to tumor challenges. This chapter
discusses the experiments that fractionate cancer-derived proteins and test them for their
ability to immunize against the cancers. The heat shock proteins (HSPs) are the most highly
conserved and abundant proteins in living systems; found across the phylogenetic ladder
from archaebacteria to primates. The basis of tumor-specific immunogenicity of HSPs lies at …
for the cancer-derived molecules, which elicit resistance to tumor challenges. This chapter
discusses the experiments that fractionate cancer-derived proteins and test them for their
ability to immunize against the cancers. The heat shock proteins (HSPs) are the most highly
conserved and abundant proteins in living systems; found across the phylogenetic ladder
from archaebacteria to primates. The basis of tumor-specific immunogenicity of HSPs lies at …