The neurodevelopmental impact of childhood onset temporal lobe epilepsy on brain structure and function and the risk of progressive cognitive effects
BP Hermann, M Seidenberg, B Bell - Progress in brain research, 2002 - Elsevier
The purpose of this study is to explore the possibility of progressive neuropsychological
decline in chronic temporal lobe epilepsy (TLE) and determine how this vulnerability may be
associated with the neurodevelopmental impact of the disorder. 53 patients with TLE and 62
healthy controls underwent quantitative MRI volumetric imaging of total brain tissue and
hippocampal volumes as well as assessment of intelligence and memory function. In
addition to reduced hippocampal volume, childhood onset (< 14 years) but not adult onset …
decline in chronic temporal lobe epilepsy (TLE) and determine how this vulnerability may be
associated with the neurodevelopmental impact of the disorder. 53 patients with TLE and 62
healthy controls underwent quantitative MRI volumetric imaging of total brain tissue and
hippocampal volumes as well as assessment of intelligence and memory function. In
addition to reduced hippocampal volume, childhood onset (< 14 years) but not adult onset …