Altered hippocampal dendritic spine maturation after hypoxia-induced seizures in neonatal rats
JJ Lippman-Bell, M Handy, CG Nieder… - Molecular and Cellular …, 2021 - Elsevier
Cognitive comorbidities often follow early-life seizures (ELS), especially in the setting of
autism and other neurodevelopmental syndromes. However, there is an incomplete
understanding of whether neuronal and synaptic development are concomitantly
dysregulated. We have previously shown that hypoxia-induced seizures (HS) in postnatal
day (P) 10 rats increase acute and later-life hippocampal glutamatergic neurotransmission
and spontaneous recurrent seizures, and impair cognition and behavior. As dendritic spines …
autism and other neurodevelopmental syndromes. However, there is an incomplete
understanding of whether neuronal and synaptic development are concomitantly
dysregulated. We have previously shown that hypoxia-induced seizures (HS) in postnatal
day (P) 10 rats increase acute and later-life hippocampal glutamatergic neurotransmission
and spontaneous recurrent seizures, and impair cognition and behavior. As dendritic spines …