[HTML][HTML] The nitrilase superfamily: classification, structure and function
HC Pace, C Brenner - Genome biology, 2001 - Springer
HC Pace, C Brenner
Genome biology, 2001•SpringerThe nitrilase superfamily consists of thiol enzymes involved in natural product biosynthesis
and post-translational modification in plants, animals, fungi and certain prokaryotes. On the
basis of sequence similarity and the presence of additional domains, the superfamily can be
classified into 13 branches, nine of which have known or deduced specificity for specific
nitrile-or amide-hydrolysis or amide-condensation reactions. Genetic and biochemical
analysis of the family members and their associated domains assists in predicting the …
and post-translational modification in plants, animals, fungi and certain prokaryotes. On the
basis of sequence similarity and the presence of additional domains, the superfamily can be
classified into 13 branches, nine of which have known or deduced specificity for specific
nitrile-or amide-hydrolysis or amide-condensation reactions. Genetic and biochemical
analysis of the family members and their associated domains assists in predicting the …
Abstract
The nitrilase superfamily consists of thiol enzymes involved in natural product biosynthesis and post-translational modification in plants, animals, fungi and certain prokaryotes. On the basis of sequence similarity and the presence of additional domains, the superfamily can be classified into 13 branches, nine of which have known or deduced specificity for specific nitrile- or amide-hydrolysis or amide-condensation reactions. Genetic and biochemical analysis of the family members and their associated domains assists in predicting the localization, specificity and cell biology of hundreds of uncharacterized protein sequences.
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