Ritonavir protects hippocampal neurons against oxidative stress-induced apoptosis
W Wan, PB DePetrillo - Neurotoxicology, 2002 - Elsevier
Oxidative stress plays an important role in many neurodegenerative conditions including
Alzheimer's disease and Parkinson's disease. 4-Hydroxynonenal (HNE), a lipid-soluble
aldehydic product of membrane peroxidation, has been known to decrease neuronal
survival by impairing Na+, K+, and-ATPase activity. HNE also increases neuronal
vulnerability to excitotoxic injury and disrupts homeostasis by activating proteases which
mediate the destruction of cellular protein and structure. The present study demonstrated …
Alzheimer's disease and Parkinson's disease. 4-Hydroxynonenal (HNE), a lipid-soluble
aldehydic product of membrane peroxidation, has been known to decrease neuronal
survival by impairing Na+, K+, and-ATPase activity. HNE also increases neuronal
vulnerability to excitotoxic injury and disrupts homeostasis by activating proteases which
mediate the destruction of cellular protein and structure. The present study demonstrated …