Chronic alcohol remodels prefrontal neurons and disrupts NMDAR-mediated fear extinction encoding
A Holmes, PJ Fitzgerald, KP MacPherson… - Nature …, 2012 - nature.com
A Holmes, PJ Fitzgerald, KP MacPherson, L DeBrouse, G Colacicco, SM Flynn, S Masneuf…
Nature neuroscience, 2012•nature.comAlcoholism is frequently co-morbid with post-traumatic stress disorder, but it is unclear how
alcohol affects the neural circuits mediating recovery from trauma. We found that chronic
intermittent ethanol (CIE) impaired fear extinction and remodeled the dendritic arbor of
medial prefrontal cortical (mPFC) neurons in mice. CIE impaired extinction encoding by
infralimbic mPFC neurons in vivo and functionally downregulated burst-mediating NMDA
GluN1 receptors. These findings suggest that alcohol may increase risk for trauma-related …
alcohol affects the neural circuits mediating recovery from trauma. We found that chronic
intermittent ethanol (CIE) impaired fear extinction and remodeled the dendritic arbor of
medial prefrontal cortical (mPFC) neurons in mice. CIE impaired extinction encoding by
infralimbic mPFC neurons in vivo and functionally downregulated burst-mediating NMDA
GluN1 receptors. These findings suggest that alcohol may increase risk for trauma-related …
Abstract
Alcoholism is frequently co-morbid with post-traumatic stress disorder, but it is unclear how alcohol affects the neural circuits mediating recovery from trauma. We found that chronic intermittent ethanol (CIE) impaired fear extinction and remodeled the dendritic arbor of medial prefrontal cortical (mPFC) neurons in mice. CIE impaired extinction encoding by infralimbic mPFC neurons in vivo and functionally downregulated burst-mediating NMDA GluN1 receptors. These findings suggest that alcohol may increase risk for trauma-related anxiety disorders by disrupting mPFC-mediated extinction of fear.
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