[HTML][HTML] Structural correlates of emotional response to electrical stimulation of the amygdala in subjects with PTSD
JM Avecillas-Chasin, M Justo, S Levinson… - … Clinical Research in …, 2020 - brainstimjrnl.com
The basolateral amygdala (BLA) forms a triad with the medial prefrontal cortex (mPFC) and
the hippocampus (HPC) to process incoming stimuli and orchestrate emotional responses
[1]. In post-traumatic stress disorder (PTSD), a dysfunction in this triad is characterized by a
deficit of mPFC inhibition of the BLA [2]. As a result, metabolic hyperactivity of the BLA
characterize symptomatic episodes in PTSD patients [3]. We are using deep brain
stimulation (DBS) in PTSD subjects to modulate the activity of the BLA and promote fear …
the hippocampus (HPC) to process incoming stimuli and orchestrate emotional responses
[1]. In post-traumatic stress disorder (PTSD), a dysfunction in this triad is characterized by a
deficit of mPFC inhibition of the BLA [2]. As a result, metabolic hyperactivity of the BLA
characterize symptomatic episodes in PTSD patients [3]. We are using deep brain
stimulation (DBS) in PTSD subjects to modulate the activity of the BLA and promote fear …