Different immune activation states require distinct metabolic features and activities in
immune cells. For instance, inhibition of fatty acid synthase (FASN), which catalyzes the
synthesis of long-chain fatty acids, prevents the proinflammatory response in macrophages;
however, the precise role of this enzyme in this response remains poorly defined. Consistent
with previous studies, we found here that FASN is essential for lipopolysaccharide-induced,
Toll-like receptor (TLR)-mediated macrophage activation. Interestingly, only agents that …