l-Arginine modulates CD3ζ expression and T cell function in activated human T lymphocytes
AH Zea, PC Rodriguez, KS Culotta, CP Hernandez… - Cellular …, 2004 - Elsevier
Engagement of the T cell receptor (TCR) by antigen or anti-CD3 antibody results in a cycle
of internalization and re-expression of the CD3ζ. Following internalization, CD3ζ is
degraded and replaced by newly synthesized CD3ζ on the cell surface. Here, we provide
evidence that availability of the amino acid l-arginine modulates the cycle of internalization
and re-expression of CD3ζ and cause T cell dysfunction. T cells stimulated and cultured in
presence of l-arginine, undergo the normal cycle of internalization and re-expression of …
of internalization and re-expression of the CD3ζ. Following internalization, CD3ζ is
degraded and replaced by newly synthesized CD3ζ on the cell surface. Here, we provide
evidence that availability of the amino acid l-arginine modulates the cycle of internalization
and re-expression of CD3ζ and cause T cell dysfunction. T cells stimulated and cultured in
presence of l-arginine, undergo the normal cycle of internalization and re-expression of …