[HTML][HTML] Characterization of the in vitro and in vivo properties of CFZ533, a blocking and non-depleting anti-CD40 monoclonal antibody
J Ristov, P Espie, P Ulrich, D Sickert, T Flandre… - American Journal of …, 2018 - Elsevier
The CD40-CD154 costimulatory pathway is essential for T cell–dependent immune
responses, development of humoral memory, and antigen presenting cell function. These
immune functions have been implicated in the pathology of multiple autoimmune diseases
as well as allograft rejection. We have generated CFZ533, a fully human, pathway blocking
anti-CD40 monoclonal antibody that has been modified with a N297A mutation to render it
unable to mediate Fcγ-dependent effector functions. CFZ533 inhibited CD154-induced …
responses, development of humoral memory, and antigen presenting cell function. These
immune functions have been implicated in the pathology of multiple autoimmune diseases
as well as allograft rejection. We have generated CFZ533, a fully human, pathway blocking
anti-CD40 monoclonal antibody that has been modified with a N297A mutation to render it
unable to mediate Fcγ-dependent effector functions. CFZ533 inhibited CD154-induced …
