The histopathological changes associated with allograft rejection and drug toxicity in renal transplant recipients maintained on FK506: clinical significance and …
PS Randhawa, R Shapiro, ML Jordan… - The American journal …, 1993 - journals.lww.com
The histopathological changes in 51 renal allograft biopsies from patients
immunosuppressed with FK506 were compared with those seen in 30 needle biopsies
obtained from patients on cyclosporine. The frequency and severity of rejection episodes
were similar in both groups. Tubular vacuolation and myocyte vacuolation were found to be
useful morphological markers to monitor short-term drug toxicity associated with both drugs.
Long-term administration of FK506 led to striped interstitial fibrosis and arteriolar hyalinosis …
immunosuppressed with FK506 were compared with those seen in 30 needle biopsies
obtained from patients on cyclosporine. The frequency and severity of rejection episodes
were similar in both groups. Tubular vacuolation and myocyte vacuolation were found to be
useful morphological markers to monitor short-term drug toxicity associated with both drugs.
Long-term administration of FK506 led to striped interstitial fibrosis and arteriolar hyalinosis …
