Glial transforming growth factor (TGF)-β isotypes in multiple sclerosis: differential glial expression of TGF-β1, 2 and 3 isotypes in multiple sclerosis
NS Peress, E Perillo, RJ Seidman - Journal of neuroimmunology, 1996 - Elsevier
We studied glial transforming growth factor (TGF)-β isotype expression in 14 cases of
multiple sclerosis. Acute active lesions exhibited selective TGF-β2 immunoreactivity of lesion
encircling ramified microglia. In contrast, astrocytes within chronic active white matter lesions
expressed all three isotypes. Chronic active lesions which extended into cortex exhibited
selective cortical astrocyte TGF-β2 expression. This isotype was also selectively expressed
by astrocytes in apparently normal white matter. A similar pattern of glial TGF-β expression …
multiple sclerosis. Acute active lesions exhibited selective TGF-β2 immunoreactivity of lesion
encircling ramified microglia. In contrast, astrocytes within chronic active white matter lesions
expressed all three isotypes. Chronic active lesions which extended into cortex exhibited
selective cortical astrocyte TGF-β2 expression. This isotype was also selectively expressed
by astrocytes in apparently normal white matter. A similar pattern of glial TGF-β expression …