TGF-β in the central nervous system: potential roles in ischemic injury and neurodegenerative diseases
BM Pratt, JM McPherson - Cytokine & growth factor reviews, 1997 - Elsevier
The Transforming Growth Factor-βs (TGF-β) are a group of multifunctional proteins whose
cellular sites of production and action are widely distributed throughout the body, including
the central nervous system (CNS). Within the CNS, various isoforms of TGF-β are produced
by both glial and neural cells. When evaluated in either cell culture or in vivo models, the
various isoforms of TGF-β have been shown to have potent effects on the proliferation,
function, or survival of both neurons and all three glial cell types, astrocytes, microglia and …
cellular sites of production and action are widely distributed throughout the body, including
the central nervous system (CNS). Within the CNS, various isoforms of TGF-β are produced
by both glial and neural cells. When evaluated in either cell culture or in vivo models, the
various isoforms of TGF-β have been shown to have potent effects on the proliferation,
function, or survival of both neurons and all three glial cell types, astrocytes, microglia and …