Association between tumor necrosis factor inhibitor exposure and inflammatory central nervous system events
A Kunchok, AJ Aksamit, JM Davis, OH Kantarci… - JAMA …, 2020 - jamanetwork.com
Importance Tumor necrosis factor (TNF) inhibitors are common therapies for certain
autoimmune diseases, such as rheumatoid arthritis. An association between TNF inhibitor
exposure and inflammatory central nervous system (CNS) events has been postulated but is
poorly understood. Objective To evaluate whether TNF inhibitor exposure is associated with
inflammatory demyelinating and nondemyelinating CNS events in patients with an indication
for TNF inhibitor use and to describe the spectrum of those CNS events. Design, Setting, and …
autoimmune diseases, such as rheumatoid arthritis. An association between TNF inhibitor
exposure and inflammatory central nervous system (CNS) events has been postulated but is
poorly understood. Objective To evaluate whether TNF inhibitor exposure is associated with
inflammatory demyelinating and nondemyelinating CNS events in patients with an indication
for TNF inhibitor use and to describe the spectrum of those CNS events. Design, Setting, and …