[HTML][HTML] Acute murine cytomegalovirus disrupts established transplantation tolerance and causes recipient allo-sensitization
S Yu, A Dangi, M Burnette, MM Abecassis… - American Journal of …, 2021 - Elsevier
We have previously shown that acute cytomegalovirus (CMV) infection disrupts the induction
of transplantation tolerance. However, what impact acute CMV infection would have on the
maintenance of established tolerance and on subsequent recipient allo-sensitization is a
clinically important unanswered question. Here we used an allogeneic murine islet
transplantation tolerance model to examine the impact of acute CMV infection on:(a)
disruption of established transplantation tolerance during tolerance maintenance; and (b) …
of transplantation tolerance. However, what impact acute CMV infection would have on the
maintenance of established tolerance and on subsequent recipient allo-sensitization is a
clinically important unanswered question. Here we used an allogeneic murine islet
transplantation tolerance model to examine the impact of acute CMV infection on:(a)
disruption of established transplantation tolerance during tolerance maintenance; and (b) …