Hippocampal insulin resistance and cognitive dysfunction
GJ Biessels, LP Reagan - Nature Reviews Neuroscience, 2015 - nature.com
Nature Reviews Neuroscience, 2015•nature.com
Clinical studies suggest a link between type 2 diabetes mellitus (T2DM) and insulin
resistance (IR) and cognitive dysfunction, but there are significant gaps in our knowledge of
the mechanisms underlying this relationship. Animal models of IR help to bridge these gaps
and point to hippocampal IR as a potential mediator of cognitive dysfunction in T2DM, as
well as in Alzheimer disease (AD). This Review highlights these observations and discusses
intervention studies which suggest that the restoration of insulin activity in the hippocampus …
resistance (IR) and cognitive dysfunction, but there are significant gaps in our knowledge of
the mechanisms underlying this relationship. Animal models of IR help to bridge these gaps
and point to hippocampal IR as a potential mediator of cognitive dysfunction in T2DM, as
well as in Alzheimer disease (AD). This Review highlights these observations and discusses
intervention studies which suggest that the restoration of insulin activity in the hippocampus …
Abstract
Clinical studies suggest a link between type 2 diabetes mellitus (T2DM) and insulin resistance (IR) and cognitive dysfunction, but there are significant gaps in our knowledge of the mechanisms underlying this relationship. Animal models of IR help to bridge these gaps and point to hippocampal IR as a potential mediator of cognitive dysfunction in T2DM, as well as in Alzheimer disease (AD). This Review highlights these observations and discusses intervention studies which suggest that the restoration of insulin activity in the hippocampus may be an effective strategy to alleviate the cognitive decline associated with T2DM and AD.
nature.com