Dopamine regulates brain-derived neurotrophic factor (BDNF) expression in cultured embryonic mouse striatal cells
E Küppers, C Beyer - Neuroreport, 2001 - journals.lww.com
The differentiation of striatal GABAergic neurons coincides with the perinatal establishment
of nigrostriatal dopaminergic synaptic connections. We have shown previously that
dopamine stimulates the maturation of striatal GABAergic neurons. Since BDNF also
regulates the development of GABAergic cells, we hypothesized that dopamine might affect
striatal BDNF expression. The influence of dopamine on BDNF protein/mRNA and trkB
mRNA levels was studied in neuronal and astroglia cultures of the mouse striatum …
of nigrostriatal dopaminergic synaptic connections. We have shown previously that
dopamine stimulates the maturation of striatal GABAergic neurons. Since BDNF also
regulates the development of GABAergic cells, we hypothesized that dopamine might affect
striatal BDNF expression. The influence of dopamine on BDNF protein/mRNA and trkB
mRNA levels was studied in neuronal and astroglia cultures of the mouse striatum …