Quinolinic acid and glutamatergic neurodegeneration in Caenorhabditis elegans
TL da Silveira, DC Zamberlan, LP Arantes… - Neurotoxicology, 2018 - Elsevier
Quinolinic acid (QUIN) is an endogenous neurotoxin that acts as an N-methyl-D-aspartate
receptor (NMDAR) agonist generating a toxic cascade, which can lead to
neurodegeneration. The action of QUIN in Caenorhabditis elegans and the neurotoxins that
allow the study of glutamatergic system disorders have not been carefully addressed. The
effects of QUIN on toxicological and behavioral parameters in VM487 and VC2623
transgenic, as well as wild-type (WT) animals were performed to evaluate whether QUIN …
receptor (NMDAR) agonist generating a toxic cascade, which can lead to
neurodegeneration. The action of QUIN in Caenorhabditis elegans and the neurotoxins that
allow the study of glutamatergic system disorders have not been carefully addressed. The
effects of QUIN on toxicological and behavioral parameters in VM487 and VC2623
transgenic, as well as wild-type (WT) animals were performed to evaluate whether QUIN …