Melatonin secretion after surgery
AJ Cronin, JC Keifer, MF Davies, TS King, EO Bixler - The Lancet, 2000 - thelancet.com
AJ Cronin, JC Keifer, MF Davies, TS King, EO Bixler
The Lancet, 2000•thelancet.comSleep disturbance is common postoperatively. We examined whether melatonin
concentrations were related to this disturbance in seven postoperative patients. Nocturnal
concentrations of melatonin were significantly (p= 0· 005) lower on the first than on the
second or third nights after surgery. This finding raises the possibility that melatonin
suppression and associated sleep disturbance might be prevented by melatonin
replacement.
concentrations were related to this disturbance in seven postoperative patients. Nocturnal
concentrations of melatonin were significantly (p= 0· 005) lower on the first than on the
second or third nights after surgery. This finding raises the possibility that melatonin
suppression and associated sleep disturbance might be prevented by melatonin
replacement.
Summary
Sleep disturbance is common postoperatively. We examined whether melatonin concentrations were related to this disturbance in seven postoperative patients. Nocturnal concentrations of melatonin were significantly (p=0·005) lower on the first than on the second or third nights after surgery. This finding raises the possibility that melatonin suppression and associated sleep disturbance might be prevented by melatonin replacement.
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