Objectives: Core clock genes regulate tissue-specific transcriptome oscillations that
synchronize physiologic processes throughout the body, held in phase by the central
circadian rhythm. The central circadian rhythm rapidly dampens with onset of critical illness,
but the effect of critical illness on gene expression oscillations is unknown. The objective of
this study was to characterize the rhythmicity and phase coherence of core clock genes and
the broader transcriptome after onset of critical illness. Design: Cross-sectional study …