Sequential activation of inflammatory signaling pathways during graft-versus-host disease (GVHD): early role for STAT1 and STAT3
HH Ma, J Ziegler, C Li, A Sepulveda, A Bedeir… - Cellular …, 2011 - Elsevier
The aim of this study was to delineate the temporal and spatial sequence of STAT1 and
STAT3 activation during development of GVHD following fully Major Histocompatibility
Complex (MHC)-mismatched allogeneic Bone Marrow Transplantation (BMT). Activation of
inflammatory signaling pathways in GVHD target organs was assessed by western blotting,
phospho-flow cytometry and electromobility shift assays (EMSA). Development of GVHD
was associated with significant expansion of phospho [p]-STAT1 and p-STAT3 expressing …
STAT3 activation during development of GVHD following fully Major Histocompatibility
Complex (MHC)-mismatched allogeneic Bone Marrow Transplantation (BMT). Activation of
inflammatory signaling pathways in GVHD target organs was assessed by western blotting,
phospho-flow cytometry and electromobility shift assays (EMSA). Development of GVHD
was associated with significant expansion of phospho [p]-STAT1 and p-STAT3 expressing …
