[HTML][HTML] Ubiquitin-mediated regulation of CD86 protein expression by the ubiquitin ligase membrane-associated RING-CH-1 (MARCH1)
K Corcoran, M Jabbour, C Bhagwandin… - Journal of biological …, 2011 - ASBMB
The activation of naïve T cells requires antigen presentation by dendritic cells (DCs), and the
process of antigen presentation is regulated over the course of DC maturation. One key
aspect of this regulation is the cell surface up-regulation upon DC maturation of peptide·
MHC-II complexes and the costimulatory molecule CD86. It is now clear that these critical
induction events involve changes in ubiquitin-dependent trafficking of MHC-II and CD86 by
the E3 ligase membrane-associated RING-CH-1 (MARCH1). Although ubiquitin-dependent …
process of antigen presentation is regulated over the course of DC maturation. One key
aspect of this regulation is the cell surface up-regulation upon DC maturation of peptide·
MHC-II complexes and the costimulatory molecule CD86. It is now clear that these critical
induction events involve changes in ubiquitin-dependent trafficking of MHC-II and CD86 by
the E3 ligase membrane-associated RING-CH-1 (MARCH1). Although ubiquitin-dependent …