SphK1 mediates hepatic inflammation in a mouse model of NASH induced by high saturated fat feeding and initiates proinflammatory signaling in hepatocytes
T Geng, A Sutter, MD Harland, BA Law, JS Ross… - Journal of lipid …, 2015 - ASBMB
Steatohepatitis occurs in up to 20% of patients with fatty liver disease and leads to its
primary disease outcomes, including fibrosis, cirrhosis, and increased risk of hepatocellular
carcinoma. Mechanisms that mediate this inflammation are of major interest. We previously
showed that overload of saturated fatty acids, such as that which occurs with metabolic
syndrome, induced sphingosine kinase 1 (SphK1), an enzyme that generates sphingosine-1-
phosphate (S1P). While data suggest beneficial roles for S1P in some contexts, we …
primary disease outcomes, including fibrosis, cirrhosis, and increased risk of hepatocellular
carcinoma. Mechanisms that mediate this inflammation are of major interest. We previously
showed that overload of saturated fatty acids, such as that which occurs with metabolic
syndrome, induced sphingosine kinase 1 (SphK1), an enzyme that generates sphingosine-1-
phosphate (S1P). While data suggest beneficial roles for S1P in some contexts, we …
