[HTML][HTML] Regulated assembly of vacuolar ATPase is increased during cluster disruption-induced maturation of dendritic cells through a phosphatidylinositol 3-kinase …
R Liberman, S Bond, MG Shainheit… - Journal of Biological …, 2014 - ASBMB
The vacuolar (H+)-ATPases (V-ATPases) are ATP-driven proton pumps composed of a
peripheral V 1 domain and a membrane-embedded V 0 domain. Regulated assembly of V 1
and V 0 represents an important regulatory mechanism for controlling V-ATPase activity in
vivo. Previous work has shown that V-ATPase assembly increases during maturation of
bone marrow-derived dendritic cells induced by activation of Toll-like receptors. This
increased assembly is essential for antigen processing, which is dependent upon an acidic …
peripheral V 1 domain and a membrane-embedded V 0 domain. Regulated assembly of V 1
and V 0 represents an important regulatory mechanism for controlling V-ATPase activity in
vivo. Previous work has shown that V-ATPase assembly increases during maturation of
bone marrow-derived dendritic cells induced by activation of Toll-like receptors. This
increased assembly is essential for antigen processing, which is dependent upon an acidic …
