Sphingosine-1-phosphate Receptor 2 Signaling Promotes Caspase-11–dependent Macrophage Pyroptosis and Worsens Escherichia coli Sepsis Outcome
F Song, J Hou, Z Chen, B Cheng, R Lei, P Cui… - …, 2018 - pubs.asahq.org
Abstract What We Already Know about This Topic No molecular-targeted treatments for
sepsis have proved successful in humans. The role of sphingosine-1-phosphate receptor 2
(S1PR2) signaling in sepsis is uncertain. What This Article Tells Us That Is New In an in vivo
mouse model of Gram-negative sepsis, deletion of the gene for sphingosine-1-phosphate
receptor 2 (S1PR2) reduced pyroptosis, possibly by decreased activation of caspase-11,
and increased survival. S1PR2 and caspase-11 may be testable targets in sepsis …
sepsis have proved successful in humans. The role of sphingosine-1-phosphate receptor 2
(S1PR2) signaling in sepsis is uncertain. What This Article Tells Us That Is New In an in vivo
mouse model of Gram-negative sepsis, deletion of the gene for sphingosine-1-phosphate
receptor 2 (S1PR2) reduced pyroptosis, possibly by decreased activation of caspase-11,
and increased survival. S1PR2 and caspase-11 may be testable targets in sepsis …
