Background & Aims Exosomes are small membrane vesicles involved in intercellular
communication. Hepatocytes are known to release exosomes, but little is known about their
biological function. We sought to determine if exosomes derived from hepatocytes contribute
to liver repair and regeneration after injury. Methods Exosomes derived from primary murine
hepatocytes were isolated and characterized biochemically and biophysically. Using
cultures of primary hepatocytes, we tested whether hepatocyte exosomes induced …