Selective export of autotaxin from the endoplasmic reticulum
L Lyu, B Wang, C Xiong, X Zhang, X Zhang… - Journal of Biological …, 2017 - ASBMB
Autotaxin (ATX) or ectonucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2) is a
secretory glycoprotein and functions as the key enzyme for lysophosphatidic acid
generation. The mechanism of ATX protein trafficking is largely unknown. Here, we
demonstrated that p23, a member of the p24 protein family, was the protein-sorting receptor
required for endoplasmic reticulum (ER) export of ATX. A di-phenylalanine (Phe-838/Phe-
839) motif in the human ATX C-terminal region was identified as a transport signal essential …
secretory glycoprotein and functions as the key enzyme for lysophosphatidic acid
generation. The mechanism of ATX protein trafficking is largely unknown. Here, we
demonstrated that p23, a member of the p24 protein family, was the protein-sorting receptor
required for endoplasmic reticulum (ER) export of ATX. A di-phenylalanine (Phe-838/Phe-
839) motif in the human ATX C-terminal region was identified as a transport signal essential …
