[HTML][HTML] Immune response to tissue-restricted self-antigens induces airway inflammation and fibrosis following murine lung transplantation
V Subramanian, S Ramachandran, B Banan… - American journal of …, 2014 - Elsevier
Immune responses against lung-associated self-antigens (self-Ags) are hypothesized to
play a role in the development of chronic lung graft rejection. We determined whether
immune responses to lung self-Ags, K-alpha-1-tubulin (Kα1T) and Collagen V (Col-V) in the
absence of alloimmunity, could promote airway inflammation and fibrosis. Following
syngeneic murine orthotopic lung transplantation (LTx) we administered antibodies (Abs) to
either Kα1T or Col-V or in combination to both of these self-Ags. As compared to recipients …
play a role in the development of chronic lung graft rejection. We determined whether
immune responses to lung self-Ags, K-alpha-1-tubulin (Kα1T) and Collagen V (Col-V) in the
absence of alloimmunity, could promote airway inflammation and fibrosis. Following
syngeneic murine orthotopic lung transplantation (LTx) we administered antibodies (Abs) to
either Kα1T or Col-V or in combination to both of these self-Ags. As compared to recipients …