[HTML][HTML] Matrix metalloproteinase inhibition decreases ischemia-reperfusion injury after lung transplantation
PM Soccal, Y Gasche, DN Miniati, G Hoyt… - American Journal of …, 2004 - Elsevier
Increased microvascular permeability and extravasation of inflammatory cells are key events
of lung ischemia-reperfusion (IR) injury. The purpose of this study was to investigate the role
of matrix metalloproteinases (MMP) in IR-induced alveolar capillary membrane disruption
after experimental lung transplantation. We used a rat model of lung orthotopic
transplantation (n= 86) with a prolonged cold ischemic phase. MMP2 and MMP9 were
elevated 4 h after the onset of ischemia and further increased during reperfusion. Compared …
of lung ischemia-reperfusion (IR) injury. The purpose of this study was to investigate the role
of matrix metalloproteinases (MMP) in IR-induced alveolar capillary membrane disruption
after experimental lung transplantation. We used a rat model of lung orthotopic
transplantation (n= 86) with a prolonged cold ischemic phase. MMP2 and MMP9 were
elevated 4 h after the onset of ischemia and further increased during reperfusion. Compared …