Impact of CMV and EBV seropositivity on CD8 T lymphocytes in an old population from West-Sicily
G Colonna-Romano, AN Akbar, A Aquino… - Experimental …, 2007 - Elsevier
Herpes viruses (particularly CMV and to some extent EBV) might play a role in accelerating
the deterioration of immune functions with age. Indeed, it has been demonstrated that
chronic infection with CMV causes an expansion of specific CD8 T lymphocytes and that this
is related to a shrinkage of the T cell repertoire in very elderly people, predicting mortality.
We have analysed CD8 T cells in young and old healthy Sicilians who were both CMV-and
EBV-seropositive. Our data confirm expansions of T cells specific for the HLA-A2-restricted …
the deterioration of immune functions with age. Indeed, it has been demonstrated that
chronic infection with CMV causes an expansion of specific CD8 T lymphocytes and that this
is related to a shrinkage of the T cell repertoire in very elderly people, predicting mortality.
We have analysed CD8 T cells in young and old healthy Sicilians who were both CMV-and
EBV-seropositive. Our data confirm expansions of T cells specific for the HLA-A2-restricted …