Nephritis as a result of autoimmunity is a common morbidity associated with Systemic Lupus
Erythematosus (SLE). There is substantial clinical and industry interest in medicinal
intervention in the SLE nephritic process; however, clinical trials to specifically treat lupus
nephritis have not resulted in complete and sustained remission in all patients. Multiple
mouse models have been used to investigate the pathologic interactions between
autoimmune reactivity and SLE pathology. While several models bear a remarkable …