Double-negative T cells in autoimmune diseases
By producing various cytokines, expanded DNT cells in inflamed tissues contribute to the
pathogenesis of a variety of autoimmune inflammatory diseases. However, it is unclear
whether this population represents a stable lineage consisting of different subsets similar to
CD4+ T helper cell subset. Better understanding of the possible heterogeneity and plasticity
of DNT cells is needed to reveal interventional therapeutic opportunities.
pathogenesis of a variety of autoimmune inflammatory diseases. However, it is unclear
whether this population represents a stable lineage consisting of different subsets similar to
CD4+ T helper cell subset. Better understanding of the possible heterogeneity and plasticity
of DNT cells is needed to reveal interventional therapeutic opportunities.
Summary
By producing various cytokines, expanded DNT cells in inflamed tissues contribute to the pathogenesis of a variety of autoimmune inflammatory diseases. However, it is unclear whether this population represents a stable lineage consisting of different subsets similar to CD4+ T helper cell subset. Better understanding of the possible heterogeneity and plasticity of DNT cells is needed to reveal interventional therapeutic opportunities.
Lippincott Williams & Wilkins