Myeloperoxidase-specific plasma cell depletion by bortezomib protects from anti-neutrophil cytoplasmic autoantibodies–induced glomerulonephritis
J Bontscho, A Schreiber, RA Manz… - Journal of the …, 2011 - journals.lww.com
Anti-neutrophil cytoplasmic autoantibodies (ANCA) cause vasculitis and necrotizing
crescentic glomerulonephritis (NCGN). Steroids and cytotoxic drugs reduce mortality but can
cause significant adverse events. The proteasome inhibitor bortezomib (BTZ) prevents
glomerulonephritis in mouse models of lupus but its efficacy in ANCA-associated
glomerulonephritis is unknown. We induced anti-MPO IgG-mediated NCGN by transplanting
wild-type bone marrow (BM) into irradiated MPO-deficient mice immunized with MPO. Four …
crescentic glomerulonephritis (NCGN). Steroids and cytotoxic drugs reduce mortality but can
cause significant adverse events. The proteasome inhibitor bortezomib (BTZ) prevents
glomerulonephritis in mouse models of lupus but its efficacy in ANCA-associated
glomerulonephritis is unknown. We induced anti-MPO IgG-mediated NCGN by transplanting
wild-type bone marrow (BM) into irradiated MPO-deficient mice immunized with MPO. Four …