[HTML][HTML] Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2
M Wang, Z Tan, R Zhang, SV Kotenko… - Journal of Biological …, 2002 - ASBMB
Interleukin 24 (IL-24) encodes a secreted protein that exhibits significant homology to the
interleukin 10 (IL-10) family of cytokines. Here we show that the human IL-24 is secreted by
activated peripheral blood mononuclear cells and is the ligand for two heterodimeric
receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2. The latter is also the receptor for IL-20.
COS cells transfected with either IL-24 receptor heterodimers bind the ligand with similar
saturation kinetics. IL-24 binding to either its endogenous receptors on human keratinocytes …
interleukin 10 (IL-10) family of cytokines. Here we show that the human IL-24 is secreted by
activated peripheral blood mononuclear cells and is the ligand for two heterodimeric
receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2. The latter is also the receptor for IL-20.
COS cells transfected with either IL-24 receptor heterodimers bind the ligand with similar
saturation kinetics. IL-24 binding to either its endogenous receptors on human keratinocytes …