Genetic and pharmacologic targeting of glycogen synthase kinase 3β reinforces the Nrf2 antioxidant defense against podocytopathy
S Zhou, P Wang, Y Qiao, Y Ge, Y Wang… - Journal of the …, 2016 - journals.lww.com
Evidence suggests that the glycogen synthase kinase 3 (GSK3)–dictated nuclear exclusion
and degradation of Nrf2 is pivotal in switching off the self-protective antioxidant stress
response after injury. Here, we examined the mechanisms underlying this regulation in
glomerular disease. In primary podocytes, doxorubicin elicited cell death and actin
cytoskeleton disorganization, concomitant with overactivation of GSK3β (the predominant
GSK3 isoform expressed in glomerular podocytes) and minimal Nrf2 activation. SB216763 …
and degradation of Nrf2 is pivotal in switching off the self-protective antioxidant stress
response after injury. Here, we examined the mechanisms underlying this regulation in
glomerular disease. In primary podocytes, doxorubicin elicited cell death and actin
cytoskeleton disorganization, concomitant with overactivation of GSK3β (the predominant
GSK3 isoform expressed in glomerular podocytes) and minimal Nrf2 activation. SB216763 …