Targeting lymphocyte signaling pathways as a therapeutic approach to systemic lupus erythematosus
VC Kyttaris, GC Tsokos - Current opinion in rheumatology, 2011 - journals.lww.com
Current opinion in rheumatology, 2011•journals.lww.com
Molecules that enhance T cell receptor (TCR) signaling or increase lymphocyte migration
can be inhibited successfully with significant improvement of disease intensity in lupus-
prone mice using small molecules. Manipulation of promoter methylation and histone
acetylation represents a novel way to alter gene transcription in SLE.
can be inhibited successfully with significant improvement of disease intensity in lupus-
prone mice using small molecules. Manipulation of promoter methylation and histone
acetylation represents a novel way to alter gene transcription in SLE.
Summary
Molecules that enhance T cell receptor (TCR) signaling or increase lymphocyte migration can be inhibited successfully with significant improvement of disease intensity in lupus-prone mice using small molecules. Manipulation of promoter methylation and histone acetylation represents a novel way to alter gene transcription in SLE.
Lippincott Williams & Wilkins