[HTML][HTML] miR-331-3p regulates ERBB-2 expression and androgen receptor signaling in prostate cancer
MicroRNAs (miRNAs) are short, non-coding RNAs that regulate gene expression and are
aberrantly expressed in human cancer. The ERBB-2 tyrosine kinase receptor is frequently
overexpressed in prostate cancer and is associated with disease progression and poor
survival. We have identified two specific miR-331-3p target sites within the ERBB-2 mRNA
3′-untranslated region and show that miR-331-3p expression is decreased in prostate
cancer tissue relative to normal adjacent prostate tissue. Transfection of multiple prostate …
aberrantly expressed in human cancer. The ERBB-2 tyrosine kinase receptor is frequently
overexpressed in prostate cancer and is associated with disease progression and poor
survival. We have identified two specific miR-331-3p target sites within the ERBB-2 mRNA
3′-untranslated region and show that miR-331-3p expression is decreased in prostate
cancer tissue relative to normal adjacent prostate tissue. Transfection of multiple prostate …