The regenerative healing response of injured skeletal muscle is dependent upon an
appropriately timed switch from a local type-I to a type-II immune response. Biologic
scaffolds derived from extracellular matrix (ECM) have been shown to facilitate a
macrophage phenotype transition that leads to downstream site-appropriate functional
tissue deposition and myogenesis. However, the mechanisms by which ECM directs the
switching of immune cell phenotype are only partially understood. Herein, we provide the …