Regulatory plasma cells
S Fillatreau - Current opinion in pharmacology, 2015 - Elsevier
Highlights•B cells can suppress immunity through production of IL-10 and IL-35.•Plasma
cells are the major source of B cell-derived IL-10 and IL-35 in vivo.•IRF4 and BLIMP-1 are
important for the regulatory function of plasma cells.•IRF4 and BLIMP-1 are important for the
suppressive function of Tregs.B cells can regulate immunity negatively or positively.
Identifying the B cell subsets mediating these antagonistic activities, and the molecular
mechanisms governing their differentiation, might enable the development of novel …
cells are the major source of B cell-derived IL-10 and IL-35 in vivo.•IRF4 and BLIMP-1 are
important for the regulatory function of plasma cells.•IRF4 and BLIMP-1 are important for the
suppressive function of Tregs.B cells can regulate immunity negatively or positively.
Identifying the B cell subsets mediating these antagonistic activities, and the molecular
mechanisms governing their differentiation, might enable the development of novel …