[HTML][HTML] Phosphorylation of the histone deacetylase 7 modulates its stability and association with 14-3-3 proteins
X Li, S Song, Y Liu, SH Ko, HY Kao - Journal of Biological Chemistry, 2004 - ASBMB
Class II histone deacetylases (HDACs) play a role in myogenesis and inhibit transcriptional
activation by myocyte enhancer factors 2. A distinct feature of class II HDACs is their ability to
shuttle between the nucleus and the cytoplasm in a cell type-and signal-dependent manner.
We demonstrate here that treatment with the 26 S proteosome inhibitors, MG132 and ALLN,
leads to detection of ubiquitinated HDAC7 and causes accumulation of cytoplasmic HDAC7.
We also show that treatment with calyculin A, a protein phosphatase inhibitor, leads to a …
activation by myocyte enhancer factors 2. A distinct feature of class II HDACs is their ability to
shuttle between the nucleus and the cytoplasm in a cell type-and signal-dependent manner.
We demonstrate here that treatment with the 26 S proteosome inhibitors, MG132 and ALLN,
leads to detection of ubiquitinated HDAC7 and causes accumulation of cytoplasmic HDAC7.
We also show that treatment with calyculin A, a protein phosphatase inhibitor, leads to a …