[HTML][HTML] Raptor and Rheb negatively regulate skeletal myogenesis through suppression of insulin receptor substrate 1 (IRS1)
The mammalian target of rapamycin (mTOR) is essential for skeletal myogenesis through
controlling distinct cellular pathways. The importance of the canonical mTOR complex 1
signaling components, including raptor, S6K1, and Rheb, had been suggested in muscle
maintenance, growth, and metabolism. However, the role of those components in myogenic
differentiation is not entirely clear. In this study we have investigated the functions of raptor,
S6K1, and Rheb in the differentiation of C2C12 mouse myoblasts. We find that although …
controlling distinct cellular pathways. The importance of the canonical mTOR complex 1
signaling components, including raptor, S6K1, and Rheb, had been suggested in muscle
maintenance, growth, and metabolism. However, the role of those components in myogenic
differentiation is not entirely clear. In this study we have investigated the functions of raptor,
S6K1, and Rheb in the differentiation of C2C12 mouse myoblasts. We find that although …