[HTML][HTML] Fenofibrate simultaneously induces hepatic fatty acid oxidation, synthesis, and elongation in mice
MH Oosterveer, A Grefhorst, TH van Dijk… - Journal of Biological …, 2009 - ASBMB
A growing body of evidence indicates that peroxisome proliferator-activated receptor α
(PPARα) not merely serves as a transcriptional regulator of fatty acid catabolism but also
exerts a much broader role in hepatic lipid metabolism. We determined adaptations in
hepatic lipid metabolism and related aspects of carbohydrate metabolism upon treatment of
C57Bl/6 mice with the PPARα agonist fenofibrate. Stable isotope procedures were applied
to assess hepatic fatty acid synthesis, fatty acid elongation, and carbohydrate metabolism …
(PPARα) not merely serves as a transcriptional regulator of fatty acid catabolism but also
exerts a much broader role in hepatic lipid metabolism. We determined adaptations in
hepatic lipid metabolism and related aspects of carbohydrate metabolism upon treatment of
C57Bl/6 mice with the PPARα agonist fenofibrate. Stable isotope procedures were applied
to assess hepatic fatty acid synthesis, fatty acid elongation, and carbohydrate metabolism …