The farnesoid X receptor (FXR) is a bile acid (BA)-activated nuclear receptor that plays a
major role in the regulation of BA and lipid metabolism. Recently, several studies have
suggested a potential role of FXR in the control of hepatic carbohydrate metabolism, but its
contribution to the maintenance of peripheral glucose homeostasis remains to be
established. FXR-deficient mice display decreased adipose tissue mass, lower serum leptin
concentrations, and elevated plasma free fatty acid levels. Glucose and insulin tolerance …