[HTML][HTML] The undernourished neonatal mouse metabolome reveals evidence of liver and biliary dysfunction, inflammation, and oxidative stress
GA Preidis, MA Keaton, PM Campeau, BC Bessard… - The Journal of …, 2014 - Elsevier
Undernutrition contributes to half of all childhood deaths under the age of 5 y, and confers
upon survivors a life-long predisposition to obesity, type 2 diabetes, and cardiovascular
disease. Mechanisms underlying the link between early nutrient deprivation and
noncommunicable diseases are unknown. Using outbred CD1 neonatal mice, we measured
metabolic profile differences between conventionally reared mice given unrestricted access
to nursing, the control group, and undernourished mice subjected to protein-calorie …
upon survivors a life-long predisposition to obesity, type 2 diabetes, and cardiovascular
disease. Mechanisms underlying the link between early nutrient deprivation and
noncommunicable diseases are unknown. Using outbred CD1 neonatal mice, we measured
metabolic profile differences between conventionally reared mice given unrestricted access
to nursing, the control group, and undernourished mice subjected to protein-calorie …