No Lewy pathology in monkeys with over 10 years of severe MPTP Parkinsonism
Movement disorders: official journal of the Movement Disorder Society, 2009•Wiley Online Library
The recent knowledge that 10 years after transplantation surviving human fetal neurons
adopt the histopathology of Parkinson's disease suggests that Lewy body formation takes a
decade to achieve. To determine whether similar histopathology occurs in 1‐methyl‐4‐
phenyl‐1, 2, 3, 6‐tetrahydropyridine (MPTP)‐primate models over a similar timeframe, the
brains of two adult monkeys made parkinsonian in their youth with intermittent injections of
MPTP were studied. Despite substantial nigral degeneration and increased α‐synuclein …
adopt the histopathology of Parkinson's disease suggests that Lewy body formation takes a
decade to achieve. To determine whether similar histopathology occurs in 1‐methyl‐4‐
phenyl‐1, 2, 3, 6‐tetrahydropyridine (MPTP)‐primate models over a similar timeframe, the
brains of two adult monkeys made parkinsonian in their youth with intermittent injections of
MPTP were studied. Despite substantial nigral degeneration and increased α‐synuclein …
Abstract
The recent knowledge that 10 years after transplantation surviving human fetal neurons adopt the histopathology of Parkinson's disease suggests that Lewy body formation takes a decade to achieve. To determine whether similar histopathology occurs in 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)‐primate models over a similar timeframe, the brains of two adult monkeys made parkinsonian in their youth with intermittent injections of MPTP were studied. Despite substantial nigral degeneration and increased α‐synuclein immunoreactivity within surviving neurons, there was no evidence of Lewy body formation. This suggests that MPTP‐induced oxidative stress and inflammation per se are not sufficient for Lewy body formation, or Lewy bodies are human specific. © 2009 Movement Disorder Society
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