[HTML][HTML] Functional cloning and characterization of a novel nonhomeodomain protein that inhibits the binding of PBX1-HOX complexes to DNA
C Abramovich, WF Shen, N Pineault, S Imren… - Journal of Biological …, 2000 - ASBMB
PBX1 is a homeodomain protein that functions in complexes with other homeodomain-
containing proteins to regulate gene expression during developmental and/or differentiation
processes. A yeast two-hybrid screen of a fetal liver-hematopoietic cDNA library using
PBX1a as bait led to the discovery of a novel non-homeodomain-containing protein that
interacts with PBX1 as well as PBX2 and PBX3. RNA analysis revealed it to be expressed in
CD34+ hematopoietic cell populations enriched in primitive progenitors, as is PBX1; search …
containing proteins to regulate gene expression during developmental and/or differentiation
processes. A yeast two-hybrid screen of a fetal liver-hematopoietic cDNA library using
PBX1a as bait led to the discovery of a novel non-homeodomain-containing protein that
interacts with PBX1 as well as PBX2 and PBX3. RNA analysis revealed it to be expressed in
CD34+ hematopoietic cell populations enriched in primitive progenitors, as is PBX1; search …